The Angel Appearing to Hagar and Ishmael in the Desert, oil on canvas, 123.8x139 cm
Born in Comunanza, in the Marche (then part of the Papal States), he was the son and pupil of the painter Sebastiano Ghezzi. He painted in the style of Pietro da Cortona. Giuseppe Ghezzi was the first secretary in perpetuity for the Accademia di San Luca in Rome. He was the father of the more prominent caricaturist Pier Leone Ghezzi (born June 28, 1674). Another son, Placido, was Apostolic Protonotary. Giuseppe was also a mentor to Pietro da Pietri (1634–1721).
On December 10, 1676, he borrowed a number of privately owned works by Venetian masters and exhibited them in the cloisters of San Salvatore in Lauro in Rome. He published a book of collected poems about art that describes an academi competition.
Ghezzi died in Rome in 1721.